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Plaqueremoving vaccine no help to Alzheimer's patients
Published：2008-08-27 Click：
BEIJING, July 18 (Xinhuanet) -- Some doctors have suspected that Alzheimer's disease patients could be saved if the plaque that builds up in their brains could be removed, but a new vaccine that did just that suggests the theory is wrong. British researchers gave 64 patients with moderate Alzheimer's disease an experimental vaccine designed to eliminate plaque from their brains. Some patients were followed for up to six years. Autopsies on seven patients who died of Alzheimer's during the study showed that nearly all of the sticky beta-amyloid protein thought to be dangerous had been removed. But all patients still had severe dementia. "It may be that these toxic plaques trigger the neurodegeneration, but don't have an ongoing role," said Clive Holmes of the University of Southampton, lead author, in a press statement. The study was published Friday in the medical journal, The Lancet. Alzheimer's disease is the most common cause of dementia and affects about 25 million people worldwide. Other experts said that the study's findings pointed to a major gap in our understanding of the disease. Doctors have never been sure whether the brain plaques are the cause of Alzheimer's disease or just a side effect. Aside from the plaque build-up, scientists also think that tangles of another brain protein called tau play a major role in Alzheimer's. Because those tangles form later than the plaque, some experts think they should be the focus instead. "It may be harder to get a response from targeting plaque because that forms years before people actually have Alzheimer's," said Dr. Simon Lovestone, professor of Old Age Psychiatry at King's College in London. "By the time you do something, it may be too late." (Agencies)
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